Methylamine → HCID 10316869, Verbindung

HRID 2382225Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2382225
Cl[CH2:2][CH2:3][C@@H:4]([O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[I:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:19][NH2:20]>C(O)C>[CH3:19][NH:20][CH2:2][CH2:3][C@@H:4]([O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[I:18])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 10248728HCID 10248728, Verbindung

Produkt 1

HCID 10316869HCID 10316869, VerbindungAusbeute 97,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Compound 1-A (2.68 g, 7.2 mmole) was dissolved in an aqueous solution of ethanol (80 ml) and methylamine (160 ml), and heated to reflux for 30 h. After cooling, the solution was extracted with chloroform (100 ml, twice), and an organic layer was decanted. The organic layer was dried over anhydrous sodium sulfate, and dried by evaporation under vacuum, to obtain the product as oil (2.75 g, 97.4%).

Aufarbeitung

  1. temperatureheated
  2. temperatureto reflux for 30 h
  3. temperatureAfter cooling
  4. extractionthe solution was extracted with chloroform (100 ml
  5. customtwice), and an organic layer was decanted
  6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  7. customdried by evaporation under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-9ea7b392a9ea418592cc53c4356f519e
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08258331B2

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