Hydrochloric Acid → HCID 67059989, Verbindung

HRID 238279Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 238279
C(OC([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N+:20]([O-:22])=[O:21])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:23]>O1CCOCC1>[ClH:23].[N+:20]([C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[C:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH:10]=1)([O-:22])=[O:21]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 23587460HCID 23587460, Verbindung

Produkt 1

HCID 67059989HCID 67059989, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

4-(2-Nitrophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (0.45 g) was dissolved in a solution of hydrogen chloride in dioxane (4 N, 4 mL). After stirring for 0.5 hour at 50° C., the solvent was removed by evaporation and the residue triturated with diethyl ether to give the title compound as a white solid (0.29 g). LCMS m/z 205.2 [M+H]+. R.T.=3.80 min (Analytical Method 4).

Aufarbeitung

  1. customthe solvent was removed by evaporation
  2. customthe residue triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-8b93ee5d61b140caa810fdd15ed9460f
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642621B2

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