2,3-dihydro-1,4-benzodioxine-6-carbonyl chloride → HCID 25213507, Verbindung
Reaktionsgleichung
[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH2:15])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1.[O:16]1[C:21]2[CH:22]=[CH:23][C:24]([C:26](Cl)=[O:27])=[CH:25][C:20]=2[O:19][CH2:18][CH2:17]1>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[N:11]3[N:12]=[C:13]([NH:15][C:26]([C:24]4[CH:23]=[CH:22][C:21]5[O:16][CH2:17][CH2:18][O:19][C:20]=5[CH:25]=4)=[O:27])[N:14]=[C:10]3[CH:9]=[CH:8][CH:7]=2)=[CH:2]1Komponenten
3
Versuchsvorschrift
The title compound was prepared following procedure and work up described for example 19, but starting from 5-(3-furyl)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A2), 50 mg; 0.25 mmol; 1.0 eq.) and 2,3-dihydro-1,4-benzodioxine-6-carbonyl chloride (74 mg; 0.37 mmol; 1.5 eq.) as a white powder (34 mg, 37%). HPLC, Rt: 3.17 min. (purity 81.5%). LC/MS, M+(ESI): 363.0.
Quellen und Nachweise
- ORD-Eintrag
- ord-6d08bd79e28049fbafa0e1d3115f4145
- Quelldatensatz
- uspto-grants-2012_09