4-tert-Butylcyclohexylamine → HCID 59437467, Verbindung
Reaktionsgleichung
Cl[C:2]1[N:7]2[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]3[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=3)[N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[C:20]([CH:24]1[CH2:29][CH2:28][CH:27]([NH2:30])[CH2:26][CH2:25]1)([CH3:23])([CH3:22])[CH3:21]>>[C:20]([CH:24]1[CH2:25][CH2:26][CH:27]([NH:30][C:2]2[N:7]3[N:8]=[C:9]([NH:11][C:12](=[O:19])[C:13]4[CH:18]=[CH:17][CH:16]=[N:15][CH:14]=4)[N:10]=[C:6]3[CH:5]=[CH:4][CH:3]=2)[CH2:28][CH2:29]1)([CH3:23])([CH3:21])[CH3:22]Komponenten
3
Versuchsvorschrift
The title compound was prepared following procedure and work up described for example 79 but starting from N-(5-chloro[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide ((B4), 80 mg; 0.29 mmol; 1.0 eq.) and 4-tert-butylcyclohexylamine (91 mg; 0.58 mmol; 2.0 eq.) as a white powder (32 mg, 27%). HPLC, Rt: 4.63 min. (purity 99.3%). LC/MS, M+(ESI): 393.1, M−(ESI): 391.1.
Quellen und Nachweise
- ORD-Eintrag
- ord-7bda01324f444b6387899a14036cb06c
- Quelldatensatz
- uspto-grants-2012_09