3-Pyridinecarbonyl chloride, hydrochloride (1:1) → HCID 59437509, Verbindung
Reaktionsgleichung
[CH:1]1([O:7][C:8]2[N:13]3[N:14]=[C:15]([NH2:17])[N:16]=[C:12]3[CH:11]=[CH:10][CH:9]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Cl.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>>[CH:1]1([O:7][C:8]2[N:13]3[N:14]=[C:15]([NH:17][C:19](=[O:26])[C:20]4[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=4)[N:16]=[C:12]3[CH:11]=[CH:10][CH:9]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1Komponenten
3
Versuchsvorschrift
The title compound was prepared following procedure and work up described for intermediate B1 but starting from 5-(cyclohexyloxy)[1,2,4]triazolo[1,5-a]pyridin-2-amine ((A11), 268 mg; 1.15 mmol; 1.0 eq.) and nicotinoyl chloride hydrochloride (247 mg; 1.38 mmol; 1.2 eq.) as an off-white foam (230 mg, 59%). HPLC, Rt: 2.36 min. (purity 94.7%). LC/MS, M−(ESI): 336.1.
Quellen und Nachweise
- ORD-Eintrag
- ord-ac40d5de7dd848d3970087fac7bce4c2
- Quelldatensatz
- uspto-grants-2012_09