Toluene → HCID 178419490, Verbindung

HRID 2383426Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2383426
[Br:1][C:2]1[C:14]2[C:13]3[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][C:8]=3[CH:7]=[N:6][C:5]=2[NH:4][N:3]=1.[F:22][C:23]([F:28])([F:27])[C:24]([OH:26])=[O:25].C1(C)C=CC=CC=1>O1CCOCC1>[F:22][C:23]([F:28])([F:27])[C:24]([O-:26])=[O:25].[Br:1][C:2]1[C:14]2[C:13]3[CH2:12][CH2:11][NH2+:10][CH2:9][C:8]=3[CH:7]=[N:6][C:5]=2[NH:4][N:3]=1

Komponenten

5

Edukt 3

HCID 1140TolueneHCID 6422Trifluoroacetic acidHCID 178451611HCID 178451611, Verbindung

Produkt 1

HCID 178419490HCID 178419490, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

To tert-butyl 1-bromo-8,9-dihydro-3H-pyrazolo[3,4-c][2,7]naphthyridine-7(6H)-carboxylate (0.23 g, 0.43 mmol) was added trifluoroacetic acid (2 mL). The reaction mixture was stirred at room temperature for 30 minutes. On completion of the reaction, toluene (3 mL) and 1,4-dioxane (2 mL) were added and the solvents removed under reduced pressure. The crude product, 1-bromo-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-7-ium 2,2,2-trifluoroacetate was obtained as brown foam and was used in the next step without any further purification. LCMS [M+H]: 253.

Aufarbeitung

  1. additionwere added
  2. customthe solvents removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-8f5cb8fa8ca84106a09a80ddd7f0c789
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08263610B2

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