4-(4-Bromophenyl)-4-hydroxypiperidine → 4-(4-Bromophenyl)-5,6-dihydropyridine

HRID 2383590Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2383590
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2(O)[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1>C(O)(C(F)(F)F)=O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:13][CH2:12][N:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Komponenten

3

Edukt 1

HCID 939114-(4-Bromophenyl)-4-hydroxypiperidine

Produkt 1

HCID 667303604-(4-Bromophenyl)-5,6-dihydropyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

A solution of 4-(4-bromophenyl)piperidin-4-ol (500 mg, 1.95 mmol) in TFA (4 mL) was heated to 90° C. for 2 h. The crude reaction mixture was concentrated under reduced pressure to dryness, to give a yellow solid (460 mg, used without further purification). MS ESI 237.9 [M+H]+, calcd for [C11H12BrN+H]+ 238.02.

Aufarbeitung

  1. customThe crude reaction mixture
  2. concentrationwas concentrated under reduced pressure to dryness
  3. customto give
  4. customa yellow solid (460 mg, used without further purification)

Quellen und Nachweise

ORD-Eintrag
ord-2e1a7dbbead94791815212ba8de2dd59
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08263596B2

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