Hydrochloric Acid → 4-(2-Methyl-benzothiazol-6-yl)-butyric acid

Reaktionsgleichung

C[O:2][C:3](=[O:17])[CH2:4][CH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([CH3:14])[S:13][C:9]=2[CH:8]=1.[OH-].[Na+].Cl>CCO>[CH3:14][C:12]1[S:13][C:9]2[CH:8]=[C:7]([CH2:6][CH2:5][CH2:4][C:3]([OH:17])=[O:2])[CH:16]=[CH:15][C:10]=2[N:11]=1

Komponenten

Versuchsvorschrift

Next, to a solution of 4-(2-methyl-benzothiazol-6-yl)-butyric acid methyl ester in EtOH (4 mL) is added aqueous 1M NaOH (4 mL) and the mixture is stirred at room temperature for 2 hours. The solution is acidified to pH 2 with aqueous 1M HCl and is extracted with ethyl acetate. The organic layer is washed with water, brine, dried over magnesium sulfate and filtered. The solvent is removed under reduced pressure to give 4-(2-methyl-benzothiazol-6-yl)-butyric acid. MS 236.3 (M+1).