Hydrochloric Acid → Pyrimidine-2,4-dicarboxylic acid

HRID 2384096Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2384096
[N:1]1[CH:6]=[CH:5][C:4]([C:7]([O:9]CC)=[O:8])=[N:3][C:2]=1[C:12]([O:14]CC)=[O:13].[OH-].[Na+].Cl>CO>[N:1]1[CH:6]=[CH:5][C:4]([C:7]([OH:9])=[O:8])=[N:3][C:2]=1[C:12]([OH:14])=[O:13]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66701935Diethyl pyrimidine-2,4-dicarboxylate

Produkt 1

HCID 45117348Pyrimidine-2,4-dicarboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Next, to a stirred solution of diethyl pyrimidine-2,4-dicarboxylate (130 mg, 0.58 mmol) in MeOH (3 mL) is added 1N NaOH (2 mL) and the mixture is stirred at room temperature for 3 hours. The solution is carefully acidified with 1N HCl and the solvent is removed under reduced pressure to give pyrimidine-2,4-dicarboxylic acid. This is used as is in subsequent reactions.

Aufarbeitung

  1. customthe solvent is removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-733ed67d8a2241ddb3d659abb439f21d
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08263629B2

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