5-Bromosalicylic acid → 5-Bromo-N-[5-bromo-4-(trifluoromethyl)thiazol-2-yl]-2-hydroxybenzamide
Reaktionsgleichung
[Br:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=O)[C:5]([OH:11])=[CH:4][CH:3]=1.[NH2:12][C:13]1[S:14][C:15]([Br:22])=[C:16]([C:18]([F:21])([F:20])[F:19])[N:17]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([NH:12][C:13]1[S:14][C:15]([Br:22])=[C:16]([C:18]([F:21])([F:19])[F:20])[N:17]=1)=[O:9]Komponenten
3
Versuchsvorschrift
Using 5-bromosalicylic acid and 2-amino-5-bromo-4-(trifluoromethyl)thiazole as the raw materials, the same operation as the example 16 gave the title compound. (2-Amino-5-bromo-4-(trifluoromethyl)thiazole: refer to J. Heterocycl. Chem., 1991, 28, 1017.)
Quellen und Nachweise
- ORD-Eintrag
- ord-75bedeb2e7ee4a6587c729efd9d41b95
- Quelldatensatz
- uspto-grants-2012_09