Reaktionsgleichung
[O:1]1[CH2:6][CH2:5][O:4][C:3]2[CH:7]=[C:8]([OH:11])[CH:9]=[CH:10][C:2]1=2.CC1C=C(O)C=CC=1C.[F:21][C:22]([F:45])([F:44])[C:23]1[O:27][C:26]([CH2:28][N:29]2[C:37]3[CH:36]=[C:35]4[O:38][CH2:39][CH2:40][O:41][C:34]4=[CH:33][C:32]=3[C:31](=[O:42])[C:30]2=[O:43])=[CH:25][CH:24]=1.C1(C(C2C=CC=CC=2)N2C3C(=CC=CC=3)C(=O)C2=O)C=CC=CC=1>>[OH:42][C:31]1([C:9]2[C:8]([OH:11])=[CH:7][C:3]3[O:4][CH2:5][CH2:6][O:1][C:2]=3[CH:10]=2)[C:32]2[CH:33]=[C:34]3[O:41][CH2:40][CH2:39][O:38][C:35]3=[CH:36][C:37]=2[N:29]([CH2:28][C:26]2[O:27][C:23]([C:22]([F:44])([F:45])[F:21])=[CH:24][CH:25]=2)[C:30]1=[O:43]Komponenten
5
Edukt 4
Produkt 1
Versuchsvorschrift
Following the procedure as described in PREPARATION 6A, and making non-critical variations using 2,3-dihydrobenzo[b][1,4]dioxin-6-ol to replace 3,4-dimethylphenol, and 6-{[5-(trifluoromethyl)furan-2-yl]methyl}-2,3-dihydro-6H-[1,4]dioxino[2,3-f]indole-7,8-dione to replace 1-(diphenylmethyl)-1H-indole-2,3-dione, 8-hydroxy-8-(7-hydroxy-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-6-((5-(trifluoromethyl)furan-2-yl)methyl)-6,8-dihydro-2H-[1,4]dioxino[2,3-f]indol-7(3H)-one was obtained (80%): 1H NMR (300 MHz, CDCl3) δ8.78 (s, 1H), 7.07-6.97 (m, 1H), 6.71-6.65 (m, 1H), 6.60-6.55 (m, 1H), 6.51-6.47 (m, 1H), 6.40-6.35 (m, 1H), 6.31-6.25 (m, 1H), 4.89-4.69 (m, 2H), 4.34-4.04 (m, 9H); MS (ES+) m/z 487.9 (M−17).
Quellen und Nachweise
- ORD-Eintrag
- ord-5a3e31354ecd4090b689f594a9a62871
- Quelldatensatz
- uspto-grants-2012_09
- Patentnummer
- US08263606B2
Verknüpfte Notizen
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