Thionyl Chloride → 2-Fluoropyridine-3-carbonyl chloride

HRID 238523

Reaktionsgleichung

Reaktionsgleichung von HRID 238523
[F:1][C:2]1[C:7]([C:8]([OH:10])=O)=[CH:6][CH:5]=[CH:4][N:3]=1.O=S(Cl)[Cl:13]>>[F:1][C:2]1[C:7]([C:8]([Cl:13])=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 960892-Fluoronicotinic acid

Produkt 1

HCID 219595822-Fluoropyridine-3-carbonyl chloride

Versuchsvorschrift

2-Fluoropyridine-3-carboxylic acid (7 g, Step C) was suspended in SOCl2 (100 mL). After heating under reflux for 2 h, the mixture became homogeneous. Excess SOCl2 was removed in vacuo to afford a brown solid as desired product.

Aufarbeitung

  1. temperatureAfter heating
  2. temperatureunder reflux for 2 h
  3. customExcess SOCl2 was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-9a43b48ccf53428fb07ec0624f068c33
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08642624B2

Verknüpfte Notizen

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