1-Fluoro-4-(methylsulphonyl)benzene → [6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-Fluoro-4-(methylsulphonyl)benzene	HCID 67994	—
Edukt	(6-Chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester	HCID 59326538	—
Edukt	2-(4-Fluoro-benzylidene)-succinic acid 1-methyl ester	HCID 67303799	—
Produkt	[6-Chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester	HCID 59326613	33,4%

Reaktionsschritte

Starting with (6-chloro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester (132 mg, 0.5 mmol) and 1-fluoro-4-methanesulfonyl-benzene (174 mg, 1.0 mmol), using a method analogous to the one described for the methyl ester of example 1-1, [6-chloro-4-(4-methanesulfonyl-phenoxy)-3-methyl-naphthalen-2-yl]-acetic acid methyl ester (70 mg, 33%) was obtained as a yellow oil.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08642629B2
Quelldatensatz	uspto-grants-2014_02
ORD ID	ord-a59767866add42b69dd7390a8d6045d1
Quellennotiz	uspto-grants-2014_02