HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Tyramine → 4-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Tyramine | HCID 5610 | — |
| Edukt | 2-Chloro-4-(3-dimethoxymethyl-phenyl)-pyrimidine | HCID 86603261 | — |
| Produkt | 4-{2-[4-(3-Dimethoxymethyl-phenyl)-pyrimidin-2-ylamino]-ethyl}-phenol | HCID 67045057 | 35% |
Reaktionsschritte
Intermediate 26 was coupled with tyramine following procedure F. The product was purified by flash chromatography using 99:1 CH2Cl2:MeOH as eluent. Yield: 35%. LC-MS showed the product had the expected M+H+ of 366.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08268822B2 |
| Quelldatensatz | uspto-grants-2012_09 |
| ORD ID | ord-97d76e7e6a82413193ca79b857e8ffe9 |
| Quellennotiz | uspto-grants-2012_09 |