6-Chloro-8-oxa-3,5-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),3,5,10,12-hexaene → N4-[2-([1]benzofuro[3,2-d]pyrimidin-4-ylamino)ethyl]pyrimidine-2,4-diamine

HRID 2386999Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2386999
Cl[C:2]1[C:3]2[O:10][C:9]3[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=3[C:4]=2[N:5]=[CH:6][N:7]=1.Cl.Cl.[NH2:17][CH2:18][CH2:19][NH:20][C:21]1[CH:26]=[CH:25][N:24]=[C:23]([NH2:27])[N:22]=1>>[N:5]1[C:4]2[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[O:10][C:3]=2[C:2]([NH:17][CH2:18][CH2:19][NH:20][C:21]2[CH:26]=[CH:25][N:24]=[C:23]([NH2:27])[N:22]=2)=[N:7][CH:6]=1

Komponenten

3

Edukt 2

HCID 6092956-Chloro-8-oxa-3,5-diazatricyclo[7.4.0.0,2,7]trideca-1(9),2(7),3,5,10,12-hexaeneHCID 86638141N4-(2-aminoethyl)pyrimidine-2,4-diamine dihydrochloride

Produkt 1

HCID 44609562N4-[2-([1]benzofuro[3,2-d]pyrimidin-4-ylamino)ethyl]pyrimidine-2,4-diamine

Versuchsvorschrift

4-Chloro-benzo[4,5]furo[3,2-d]pyrimidine (50 mg, 0.244 mmol) and the product of Example 1E (72 mg, 0.318 mmol) were treated under the conditions of Example 1F to afford the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 3.59-3.85 (m, 4H) 6.03 (d, J=7.12 Hz, 1H) 7.52 (t, J=7.46 Hz, 1H) 7.58-7.67 (m, 1H) 7.67-7.88 (m, 4H) 8.11 (d, J=7.12 Hz, 1H) 8.28-8.44 (m, 1H) 8.82 (t, J=5.43 Hz, 1H) 11.69 (s, 1H); MS (ESI+) m/z 322.0 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-5bec58ecc754492f840980aee74bef58
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268846B2

Notizen zur Reaktion

Wird geladen…