Trifluoroacetic acid → 5-(3-Aminopropyl)-6-methyl-N4-pentylpyrimidine-2,4-diamine

HRID 2387775Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2387775
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][CH2:10][CH2:11][NH:12]C(=O)OC(C)(C)C)=[C:4]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])[N:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:12][CH2:11][CH2:10][CH2:9][C:5]1[C:4]([NH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])=[N:3][C:2]([NH2:1])=[N:7][C:6]=1[CH3:8]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 86633392tert-Butyl 3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylcarbamate

Produkt 1

HCID 98378705-(3-Aminopropyl)-6-methyl-N4-pentylpyrimidine-2,4-diamineAusbeute 84,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The product from step (iv) (3.8 g) was dissolved in DCM (100 mL) and TFA (35 mL) and the reaction mixture stirred at rt for 16 h. The solvent was evaporated and the residue taken up in MeOH. The product was purified via SCX resin to give the subtitle compound 2.3 g.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customThe product was purified via SCX resin

Quellen und Nachweise

ORD-Eintrag
ord-3536eadc8f9947bd9ec6b6e8884818bd
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268990B2

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