Imidazole → HCID 86633411, Verbindung

HRID 2387866Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2387866
[NH2:1][CH2:2][C@@H:3]([OH:6])[CH2:4][CH3:5].[C:7]([Si:11](Cl)([CH3:13])[CH3:12])([CH3:10])([CH3:9])[CH3:8].N1C=CN=C1>CN(C=O)C>[Si:11]([O:6][C@@H:3]([CH2:4][CH3:5])[CH2:2][NH2:1])([C:7]([CH3:10])([CH3:9])[CH3:8])([CH3:13])[CH3:12]

Komponenten

5

Edukt 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 6995554(2S)-1-Amino-2-butanol

Produkt 1

HCID 86633411HCID 86633411, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To the product from step (ii) (310 mg) in DMF (10 mL), tert-butylchlorodimethylsilane (734 mg) was added followed by imidazole (474 mg) and stirred at rt for 24 h. The mixture was washed with water and extracted with EtOAc, dried and the solvent removed to give the subtitle compound as a yellow oil, 610 mg.

Aufarbeitung

  1. washThe mixture was washed with water
  2. extractionextracted with EtOAc
  3. customdried
  4. customthe solvent removed

Quellen und Nachweise

ORD-Eintrag
ord-b3232efce3c34bd9b858e2e9481ecf73
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268990B2

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