Methanol → Methyl 2-(3-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate

HRID 2387871Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2387871
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([CH2:18][C:19]([OH:21])=[O:20])[CH:13]=[CH:14][C:15]=2[O:16][CH3:17])=[C:4]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[N:3]=1.[CH3:28]O>Cl.O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([CH2:18][C:19]([O:21][CH3:28])=[O:20])[CH:13]=[CH:14][C:15]=2[O:16][CH3:17])=[C:4]([NH:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[N:3]=1

Komponenten

5

Edukt 2

HCID 887MethanolHCID 684129432-(3-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetic acid

Produkt 1

HCID 42613398Methyl 2-(3-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of the product from step (iv) (135 mg) in MeOH (5 ml) and 4M HCl in dioxane (0.5 ml) was stirred at rt for 18 h. The solvent was evaporated and the residue purified by RPHPLC to give the title compound as a solid, 31 mg.

Aufarbeitung

  1. customThe solvent was evaporated
  2. customthe residue purified by RPHPLC

Quellen und Nachweise

ORD-Eintrag
ord-f5fd2a3573004cad97088dd7e8cc52e9
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268990B2

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