Ethanol → 2-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetic acid

HRID 2387910Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2387910
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([S:13][C:14]2[CH:19]=[CH:18][C:17](CC#N)=[CH:16][CH:15]=2)=[C:4]([CH3:23])[N:3]=1.[OH-:24].[K+].[CH3:26][CH2:27][OH:28]>>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([S:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:26][C:27]([OH:24])=[O:28])=[CH:16][CH:15]=2)=[C:4]([CH3:23])[N:3]=1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 684153862-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetonitrile

Produkt 1

HCID 684157402-(4-(2-Amino-4-(butylamino)-6-methylpyrimidin-5-ylthio)phenyl)acetic acid

Versuchsvorschrift

A mixture of the product from step (v) (610 mg) and aq. SM KOH (2 ml) in EtOH (8 ml) was heated under reflux for 18 h. The mixture was purified by RPHPLC to give the subtitle compound as a solid, 392 mg.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 18 h
  3. customThe mixture was purified by RPHPLC

Quellen und Nachweise

ORD-Eintrag
ord-b350b676971f41718a70ebfa290db11a
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268990B2

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