2-Hydroxy-5-iodopyridine → 1-[2-(Tert-butyl-dimethyl-silanyloxy)-ethyl]-5-iodo-1h-pyridin-2-one
Reaktionsgleichung
[I:1][C:2]1[CH:3]=[CH:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][CH2:11][O:12][Si:13]([C:16]([CH3:19])([CH3:18])[CH3:17])([CH3:15])[CH3:14]>>[C:16]([Si:13]([CH3:15])([CH3:14])[O:12][CH2:11][CH2:10][N:6]1[CH:7]=[C:2]([I:1])[CH:3]=[CH:4][C:5]1=[O:8])([CH3:19])([CH3:18])[CH3:17]Komponenten
3
Versuchsvorschrift
The title compounds were prepared as white solids from the alkylation of 5-iodo-1H-pyridin-2-one with BrCH2CH2OTBS (Aldrich) using the procedure described in Step A of Example 38.
Quellen und Nachweise
- ORD-Eintrag
- ord-d306150ea5e04358981d6b7144b69b65
- Quelldatensatz
- uspto-grants-2012_09
- Patentnummer
- US08269015B2
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