Trifluoroacetic acid → HCID 57916235, Verbindung

HRID 2388662Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2388662
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[S:9]([N:12]([CH2:16][CH2:17][O:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])[CH:13]1[CH2:15][CH2:14]1)(=[O:11])=[O:10].FC(F)(F)C(O)=O>ClCCl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[S:9]([N:12]([CH2:16][CH2:17][O:18][CH2:19][C:20]([OH:22])=[O:21])[CH:13]1[CH2:14][CH2:15]1)(=[O:10])=[O:11]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 57916276tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetate

Produkt 1

HCID 57916235HCID 57916235, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a dichloromethane (10 ml/mmol) solution of tert-butyl 2-(2-(2-chloro-N-cyclopropyl-6-methylphenylsulfonamido)ethoxy)acetate (1 eq.) was added trifluoroacetic acid (13 eq.) at 0° C. and the resulting reaction mixture was stirred at ambient temperature for 2 h. The solvent was evaporated off and the residue dried under vacuum to remove traces of trifluoroacetic acid. The crude product was used in the next step without further purification. Yield: quantitative

Aufarbeitung

  1. customthe resulting reaction mixture
  2. customThe solvent was evaporated off
  3. customthe residue dried under vacuum
  4. customto remove traces of trifluoroacetic acid
  5. customThe crude product was used in the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b0de5525e311437eb2cd016bd7b2640e
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268814B2

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