Hydrochloric Acid → HCID 68643985, Verbindung

HRID 2388670Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2388670
[ClH:1].[OH:2][CH2:3][C@@H:4]1[CH2:13][CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]1C(OC(C)(C)C)=O>CO>[ClH:1].[NH:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH2:12][CH2:13][C@H:4]1[CH2:3][OH:2]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 57263166HCID 57263166, Verbindung

Produkt 1

HCID 68643985HCID 68643985, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Hydrogen chloride in methanol (1.25 mol/l, 60 ml) was added to (S)-tert-butyl 2-(hydroxymethyl)-3,4-dihydroquinoline-1(2H)-carboxylate (3.98 g, 15.1 mmol) and the mixture was refluxed for 2 h. The solvent was removed in vacuo, the residue was taken up in ethanol (5 ml) and the mixture was cooled. Diethylether (200 ml) was added and the mixture was stirred in an ice bath for 30 min. The precipitate was filtered out with suction, washed with diethylether and dried in vacuo.

Aufarbeitung

  1. temperaturethe mixture was refluxed for 2 h
  2. customThe solvent was removed in vacuo
  3. temperaturethe mixture was cooled
  4. additionDiethylether (200 ml) was added
  5. filtrationThe precipitate was filtered out with suction
  6. washwashed with diethylether
  7. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-05f1bd327e674993b3f39a04b1cb44bd
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08268814B2

Notizen zur Reaktion

Wird geladen…