HCID 86619885, Verbindung → 1,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

HRID 2388841Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2388841
C([NH:5][S:6]([C:9]1[CH:18]=[C:17]2[C:12]([CH2:13][CH2:14][N:15](C(=O)C(F)(F)F)[CH2:16]2)=[CH:11][CH:10]=1)(=[O:8])=[O:7])(C)(C)C>C(O)(C(F)(F)F)=O>[CH2:16]1[C:17]2[C:12](=[CH:11][CH:10]=[C:9]([S:6]([NH2:5])(=[O:7])=[O:8])[CH:18]=2)[CH2:13][CH2:14][NH:15]1

Komponenten

3

Edukt 1

HCID 86619885HCID 86619885, Verbindung2×

Produkt 1

HCID 52261,2,3,4-Tetrahydroisoquinoline-7-sulfonamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

N-(tert-Butyl)-2-(trifluoroacetyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide (the product from step i), 1.78 g) was dissolved in TFA and stirred at room temperature for 96 h. The reaction was reduced in vacuo and the residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane to give the subtitle compound as a white solid. Yield: 0.65 g

Aufarbeitung

  1. customthe residue purified by column chromatography on silica gel 50% EtOAc/50% iso-hexane

Quellen und Nachweise

ORD-Eintrag
ord-dad070b6548e4e229595b46ac85a0933
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08269002B2

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