HCID 178445744, Verbindung → HCID 178447443, Verbindung
Reaktionsgleichung
C([C@H]1CC[C@H](OC2C(C(F)(F)F)=C3C(=CC=2)C=C(C([N+]([O-])=O)CCC(O)=O)C=C3)CC1)(C)(C)C.[C:35]([C@H:39]1[CH2:44][CH2:43][C@H:42]([O:45][C:46]2[CH:47]=[C:48]3[C:53](=[CH:54][CH:55]=2)[CH:52]=[C:51]([C:56]([N+:64]([O-:66])=[O:65])([CH3:63])[CH2:57][CH2:58][C:59]([O:61]C)=[O:60])[CH:50]=[CH:49]3)[CH2:41][CH2:40]1)([CH3:38])([CH3:37])[CH3:36]>>[C:35]([C@H:39]1[CH2:40][CH2:41][C@H:42]([O:45][C:46]2[CH:47]=[C:48]3[C:53](=[CH:54][CH:55]=2)[CH:52]=[C:51]([C:56]([N+:64]([O-:66])=[O:65])([CH3:63])[CH2:57][CH2:58][C:59]([OH:61])=[O:60])[CH:50]=[CH:49]3)[CH2:43][CH2:44]1)([CH3:38])([CH3:36])[CH3:37]Komponenten
3
Versuchsvorschrift
4-(6-(trans-4-tert-butylcyclohexyloxy)naphthalen-2-yl)-4-nitropentanoic acid was synthesized as per 4-(6-(trans-4-tert-butylcyclohexyloxy)-5-(trifluoromethyl)naphthalen-2-yl)-4-nitrobutanoic acid (Example 202) in 96% yield using methyl 4-(6-(trans-4-tert-butylcyclohexyloxy) naphthalen-2-yl)-4-nitropentanoate as starting material.
Quellen und Nachweise
- ORD-Eintrag
- ord-2a1f9b4157ed49839d37751622f76043
- Quelldatensatz
- uspto-grants-2012_09