Dichloromethane → 4-(2-Cyano-1-benzofuran-5-yl)piperazin-1-ium chloride

HRID 2389270Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2389270
[C:1]([C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)=[CH:8][C:6]=2[CH:7]=1)#[N:2].C(Cl)[Cl:26]>CCOC(C)=O>[Cl-:26].[C:1]([C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([N:12]3[CH2:17][CH2:16][NH2+:15][CH2:14][CH2:13]3)=[CH:8][C:6]=2[CH:7]=1)#[N:2]

Komponenten

4

Edukt 2

HCID 6344DichloromethaneHCID 67154775Tert-butyl 4-(2-cyano-1-benzofuran-5-yl)piperazine-1-carboxylate

Produkt 1

HCID 671549194-(2-Cyano-1-benzofuran-5-yl)piperazin-1-ium chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The above piperazine (85.3 mg, 0.261 mmol) was dissolved in 5 mL of DCM and 5 mL of EtOAc, and cooled to 0° C. Hydrogen chloride gas was bubbled through the mixture for 30 seconds. The reaction stirred for 30 minutes, warming to ambient temperature. The slurry was concentrated to afford 4-(2-cyano-1-benzofuran-5-yl)piperazin-1-ium chloride.

Aufarbeitung

  1. customHydrogen chloride gas was bubbled through the mixture for 30 seconds
  2. concentrationThe slurry was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-c928fe962c8f4c38b5c9417102e38a94
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273737B2

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