Potassium Hydroxide → HCID 178517804, Verbindung

HRID 2389765Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2389765
[Cl:1][C:2]1[N:7]=[C:6](SC)[N:5]2[N:10]=[CH:11][N:12]=[C:4]2[CH:3]=1.[OH-:13].[K+]>CO>[Cl:1][C:2]1[N:7]=[C:6]([OH:13])[N:5]2[N:10]=[CH:11][N:12]=[C:4]2[CH:3]=1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 592990517-Chloro-5-methylsulfanyl-[1,2,4]triazolo[1,5-c]pyrimidine

Produkt 1

HCID 178517804HCID 178517804, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 2.58 g (12.9 mmol) of 7-chloro-5-(methylthio)[1,2,4]triazolo[1,5-c]pyrimidine (Example 51A) is dissolved in 300 ml of methanol, and 28 ml of a 2 molar aqueous potassium hydroxide solution are added. The mixture is heated under reflux for 3 h. After the reaction is complete, the methanol is removed in vacuo, the mixture is neutralized with half-concentrated hydrochloric acid, and the crystals which have separated out are filtered off with suction. They are washed with water and methanol and then dried under high vacuum. 1.82 g (83% of theory) of the product are obtained.

Aufarbeitung

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 3 h
  3. customthe methanol is removed in vacuo
  4. customthe crystals which have separated out
  5. filtrationare filtered off with suction
  6. washThey are washed with water and methanol
  7. customdried under high vacuum
  8. custom1.82 g (83% of theory) of the product are obtained

Quellen und Nachweise

ORD-Eintrag
ord-174a4fc9605d41ceb0b3809fad5dcc41
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273752B2

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