Furo[3,2-c]pyrazolo[1,5-a]pyridin-1-ylacetonitrile → 2-Furo[3,2-c]pyrazolo[1,5-a]pyridin-1-ylethanamine

HRID 2389885Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2389885
[C:1]1([CH2:13][C:14]#[N:15])[CH:2]=[N:3][N:4]2[CH:9]=[CH:8][C:7]3[O:10][CH:11]=[CH:12][C:6]=3[C:5]=12>N.CO.[Co]>[C:1]1([CH2:13][CH2:14][NH2:15])[CH:2]=[N:3][N:4]2[CH:9]=[CH:8][C:7]3[O:10][CH:11]=[CH:12][C:6]=3[C:5]=12

Komponenten

4

Edukt 1

HCID 59179369Furo[3,2-c]pyrazolo[1,5-a]pyridin-1-ylacetonitrile

Produkt 1

HCID 591794582-Furo[3,2-c]pyrazolo[1,5-a]pyridin-1-ylethanamineAusbeute 99 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 104730CobaltKatalysatorHCID 21705897Ammonia methanolLösungsmittel

Versuchsvorschrift

Furo[3,2-c]pyrazolo[1,5-a]pyridin-1-ylacetonitrile (55.0 mg, 0.279 mmol) and Raney cobalt (500 mg) were suspended in 2M ammonia/methanol solution (10 mL), and the suspension was stirred at room temperature for 3 hr under a hydrogen atmosphere. The catalyst was filtered through celite, and the filtrate was concentrated under reduced pressure to give the title compound (55.5 mg, yield 99%).

Aufarbeitung

  1. filtrationThe catalyst was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-aa2e4dd3eef4485a87de71656a3644da
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273761B2

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