Methyl iodide → (3-hydroxypyridin-2-yl)-N,N,N-trimethylmethanaminium iodide
Reaktionsgleichung
[CH3:1][N:2]([CH2:4][C:5]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][N:6]=1)[CH3:3].[I:12][CH3:13]>CC(C)=O>[I-:12].[OH:11][C:10]1[C:5]([CH2:4][N+:2]([CH3:13])([CH3:1])[CH3:3])=[N:6][CH:7]=[CH:8][CH:9]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 2-[(dimethylamino)methyl]pyridin-3-ol (207 g, 1.37 mol) in acetone (2000 mL) was added dropwise iodomethane (778 g, 5.48 mol) under ice-cooling, and the mixture was stirred at room temperature for 3 hr. The resulting crystals were collected by filtration to give the title compound (369 g, yield 92%).
Aufarbeitung
- temperaturecooling
- filtrationThe resulting crystals were collected by filtration
Quellen und Nachweise
- ORD-Eintrag
- ord-284a51039d62448186ac07493290f9ad
- Quelldatensatz
- uspto-grants-2012_09
- Patentnummer
- US08273761B2
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