Sodium sulfate decahydrate → 2-Ethyl-8-methylfuro[3,2-c]pyrazolo[1,5-a]pyridine-1-methanol

HRID 2389930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2389930
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH2:7]([C:9]1[C:21]([C:22](OCC)=[O:23])=[C:12]2[C:13]3[CH:19]=[C:18]([CH3:20])[O:17][C:14]=3[CH:15]=[CH:16][N:11]2[N:10]=1)[CH3:8].O.O.O.O.O.O.O.O.O.O.S([O-])([O-])(=O)=O.[Na+].[Na+]>O1CCCC1>[CH2:7]([C:9]1[C:21]([CH2:22][OH:23])=[C:12]2[C:13]3[CH:19]=[C:18]([CH3:20])[O:17][C:14]=3[CH:15]=[CH:16][N:11]2[N:10]=1)[CH3:8]

Komponenten

5

Edukt 3

HCID 62649Sodium sulfate decahydrateHCID 21226445Aluminium lithium hydrideHCID 59179437Ethyl 2-ethyl-8-methylfuro[3,2-c]pyrazolo[1,5-a]pyridine-1-carboxylate

Produkt 1

HCID 591794472-Ethyl-8-methylfuro[3,2-c]pyrazolo[1,5-a]pyridine-1-methanolAusbeute 124,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

To a suspension of 80% lithium aluminum hydride (293 mg, 7.91 mmol) in tetrahydrofuran (16 mL) was added a solution of ethyl 2-ethyl-8-methylfuro[3,2-c]pyrazolo[1,5-a]pyridine-1-carboxylate (430 mg, 1.26 mmol) in tetrahydrofuran (16 mL) under ice-cooling, and the mixture was stirred at room temperature for 30 min. Sodium sulfate decahydrate (4.3 g) was added under ice-cooling, and the insoluble material was filtered off. The filtrate was concentrated under reduced pressure, and the residue was washed with diisopropyl ether to give the title compound (360 mg, yield 99%).

Aufarbeitung

  1. temperaturecooling
  2. temperaturecooling
  3. filtrationthe insoluble material was filtered off
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. washthe residue was washed with diisopropyl ether

Quellen und Nachweise

ORD-Eintrag
ord-157098d007ad4fa488254263c3ffa623
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273761B2

Notizen zur Reaktion

Wird geladen…