3-Bromo-2-methylpyridine → Tert-butyl{4-chloro-2-[(2-methylpyridin-3-yl)ethynyl]phenoxy}acetate

HRID 2390124

Reaktionsgleichung

Reaktionsgleichung von HRID 2390124
[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])([CH3:4])([CH3:3])[CH3:2].Br[C:20]1[C:21]([CH3:26])=[N:22][CH:23]=[CH:24][CH:25]=1>>[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[C:17][C:20]1[C:21]([CH3:26])=[N:22][CH:23]=[CH:24][CH:25]=1)([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 12010033-Bromo-2-methylpyridineHCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×

Produkt 1

HCID 58521928Tert-butyl{4-chloro-2-[(2-methylpyridin-3-yl)ethynyl]phenoxy}acetate

Versuchsvorschrift

Following the general method as outlined in Intermediate 19, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and 3-bromo-2-methylpyridine (Synchem-OHG), the title compound was obtained as a yellow sticky solid after purification by preparative HPLC.

Quellen und Nachweise

ORD-Eintrag
ord-ccbd8eec367c44b3b021eaff2794922d
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273769B2

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