3-Bromo-N,N,4-trimethylbenzene-1-sulfonamide → HCID 58522002, Verbindung

HRID 2390183Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2390183
[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])([CH3:4])([CH3:3])[CH3:2].[CH3:19][N:20]([CH3:32])[S:21]([C:24]1[CH:29]=[CH:28][C:27]([CH3:30])=[C:26](Br)[CH:25]=1)(=[O:23])=[O:22]>>[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[C:17][C:26]1[CH:25]=[C:24]([S:21]([N:20]([CH3:32])[CH3:19])(=[O:22])=[O:23])[CH:29]=[CH:28][C:27]=1[CH3:30])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 72133053-Bromo-N,N,4-trimethylbenzene-1-sulfonamideHCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×

Produkt 1

HCID 58522002HCID 58522002, Verbindung

Versuchsvorschrift

Following the general method as outlined in Intermediate 20, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and N,N-dimethyl 3-bromo-4-methylbenzenesulfonamide (Combiblocks), the title compound was obtained as an orange sticky solid after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Quellen und Nachweise

ORD-Eintrag
ord-f8db246070a042ab94d41cb2b771f3b0
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273769B2

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