tert-Butyl bromoacetate → Tert-butyl (2-bromo-4-fluorophenoxy)acetate

Reaktionsgleichung

[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12](Cl)=[CH:11][C:10]=1[Br:16])([CH3:4])([CH3:3])[CH3:2].BrC1C=C([F:25])C=CC=1O.BrCC(OC(C)(C)C)=O>>[C:1]([O:5][C:6](=[O:17])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([F:25])=[CH:11][C:10]=1[Br:16])([CH3:4])([CH3:3])[CH3:2]

Komponenten

Edukt 3

HCID 79177tert-Butyl bromoacetate

HCID 6054722-Bromo-4-fluorophenol

HCID 49766393tert-Butyl (2-bromo-4-chlorophenoxy)acetate

Produkt 1

HCID 59642165Tert-butyl (2-bromo-4-fluorophenoxy)acetate

Versuchsvorschrift

Following the general method as outlined in Intermediate 1, starting from 2-bromo-4-fluorophenol and tert-butyl bromoacetate, the title compound was obtained as a white solid in quantitative yield.

Quellen und Nachweise

ORD-Eintrag: ord-0f7502718cab4c3c982cdcb2c1e5dc13
Quelldatensatz: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08273769B2

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