Tert-butyl(4-chloro-2-ethynylphenoxy)acetate → Tert-butyl(4-chloro-2-{[2-ethyl-5-(methylsulfonyl)phenyl]ethynyl}phenoxy)acetate

HRID 2390205Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2390205
[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])([CH3:4])([CH3:3])[CH3:2].[CH2:19]([C:21]1[CH:26]=[CH:25][C:24]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:23][C:22]=1I)[CH3:20]>>[C:1]([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[C:17][C:22]1[CH:23]=[C:24]([S:27]([CH3:30])(=[O:28])=[O:29])[CH:25]=[CH:26][C:21]=1[CH2:19][CH3:20])([CH3:4])([CH3:3])[CH3:2]

Komponenten

3

Edukt 2

HCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×HCID 585218301-Ethyl-2-iodo-4-(methylsulfonyl)benzene2×

Produkt 1

HCID 58521866Tert-butyl(4-chloro-2-{[2-ethyl-5-(methylsulfonyl)phenyl]ethynyl}phenoxy)acetate

Versuchsvorschrift

Following the general method as outlined in Intermediate 20, starting from (4-chloro-2-ethynyl-phenoxy)-acetic acid tert-butyl ester (Intermediate 3) and 1-ethyl-2-iodo-4-(methylsulfonyl)benzene (Intermediate 123), the title compound was obtained as an orange oil after purification by flash column chromatography (silica), eluting with cyclohexane containing increasing amounts of EtOAc.

Quellen und Nachweise

ORD-Eintrag
ord-b3a4da7aec4b4fe3a674e71bd73e3912
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273769B2

Notizen zur Reaktion

Wird geladen…