N-Ethyl 3-bromo-4-methylbenzenesulfonamide → HCID 56594784, Verbindung

HRID 2390332Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2390332
C([O:5][C:6](=[O:18])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[C:16]#[CH:17])(C)(C)C.[CH2:19]([NH:21][S:22]([C:25]1[CH:30]=[CH:29][C:28]([CH3:31])=[C:27](Br)[CH:26]=1)(=[O:24])=[O:23])[CH3:20]>>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:18])=[C:10]([C:16]#[C:17][C:27]2[CH:26]=[C:25]([S:22]([NH:21][CH2:19][CH3:20])(=[O:23])=[O:24])[CH:30]=[CH:29][C:28]=2[CH3:31])[CH:11]=1

Komponenten

3

Edukt 2

HCID 7213289N-Ethyl 3-bromo-4-methylbenzenesulfonamideHCID 56594381Tert-butyl(4-chloro-2-ethynylphenoxy)acetate2×

Produkt 1

HCID 56594784HCID 56594784, Verbindung

Versuchsvorschrift

Following the general method as outlined in Example 10, starting from tert-butyl(4-chloro-2-ethynylphenoxy)acetate (Intermediate 3) and N-ethyl 3-bromo-4-methylbenzenesulfonamide (Combi-Blocks), the title compound was obtained as a beige solid after purification by preparative HPLC.

Quellen und Nachweise

ORD-Eintrag
ord-68ade3a996b44bd7b0fa1744fb64f5ae
Quelldatensatz
uspto-grants-2012_09
Patentnummer
US08273769B2

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