HCID 58521854, Verbindung → HCID 46866076, Verbindung
Reaktionsgleichung
C([O:5][C:6](=[O:19])[CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]#[N:16])=[CH:11][C:10]=1[C:17]#[CH:18])(C)(C)C.Br[C:21]1[CH:26]=[C:25]([S:27]([CH2:30][CH:31]([CH3:33])[CH3:32])(=[O:29])=[O:28])[CH:24]=[CH:23][C:22]=1[CH3:34]>>[C:15]([C:12]1[CH:13]=[CH:14][C:9]([O:8][CH2:7][C:6]([OH:5])=[O:19])=[C:10]([C:17]#[C:18][C:23]2[CH:24]=[C:25]([S:27]([CH2:30][CH:31]([CH3:32])[CH3:33])(=[O:28])=[O:29])[CH:26]=[CH:21][C:22]=2[CH3:34])[CH:11]=1)#[N:16]Komponenten
3
Versuchsvorschrift
Following the general method as outlined in Example 37, starting from tert-butyl(4-cyano-2-ethynyl phenoxy)acetate (Intermediate 46) and 2-bromo-4-(isobutylsulfonyl)-1-methylbenzene (Intermediate 66), the title compound was obtained as a yellow solid.
Quellen und Nachweise
- ORD-Eintrag
- ord-98b7499fc22b48d9a0cc1b5853cc4ac2
- Quelldatensatz
- uspto-grants-2012_09