HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylamine → 4-(7-Bromo-3-isoquinolinyl)benzonitrile
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylamine | HCID 7912 | — |
| Edukt | 4-Ethynylbenzonitrile | HCID 4547245 | — |
| Edukt | HCID 178448919 | HCID 178448919 | — |
| Katalysator | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Katalysator | HCID 178418476 | HCID 178418476 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | 4-(7-Bromo-3-isoquinolinyl)benzonitrile | HCID 67104258 | — |
Reaktionsschritte
The product from Example 62D (3.6 mmol), 4-cyanophenylacetylene (4.3 mmol), CuI (0.2 mmol), PdCl2(PPh3)2 (0.1 mmol), and diisopropylamine (5.3 mmol) can be combined in toluene (15 mL) and processed as described in Example 62E to provide the title compound.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08273767B2 |
| Quelldatensatz | uspto-grants-2012_09 |
| ORD ID | ord-1178ac53b86445799ddf47cda10da5c3 |
| Quellennotiz | uspto-grants-2012_09 |