Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium Bicarbonate | HCID 516892 | — |
| Edukt | Trimethylaluminum | HCID 16682925 | — |
| Edukt | 5-(2,2,4-Trimethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine | HCID 66914602 | — |
| Edukt | 8-(2,6-Difluoro-3,5-dimethoxyphenyl)quinoxaline-5-carboxylic acid ethyl ester | HCID 86641145 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Dichloromethane methanol | HCID 21226129 | — |
| Produkt | HCID 59292957 | HCID 59292957 | — |
Reaktionsschritte
The title compound was prepared in analogy to the procedures described in Example 115 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), 5-(2,2,4-trimethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (Step 110.1), 1.5 equiv of trimethyl aluminum, stirring the reaction mixture for 6 h at 80° C. and pouring it onto a saturated aqueous solution of NaHCO3 and DCM. Title compound: ESI-MS: 563.1 [M+H]+; tR=3.55 min (System 1); TLC: Rf=0.08 (DCM/MeOH, 95:5).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US08273882B2 |
|---|
| Quelldatensatz | uspto-grants-2012_09 |
|---|
| ORD ID | ord-c22f33710e854798a74732b77ac230cf |
|---|
| Quellennotiz | uspto-grants-2012_09 |
|---|
