Methylamine → 4-amino-N-methylbenzene-1-sulfonamide

HRID 23921Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 23921
CN.[CH2:3]([N:5](CC)CC)C.[S:10](F)(=[O:19])([C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=1)=[O:11]>C(O)C>[CH3:3][NH:5][S:10]([C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[CH:14][CH:13]=1)(=[O:19])=[O:11]

Komponenten

5

Edukt 3

HCID 6329MethylamineHCID 8471TriethylamineHCID 668234-Aminobenzenesulfonyl fluoride

Produkt 1

HCID 743684-amino-N-methylbenzene-1-sulfonamideAusbeute 78,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Methylamine (3 ml of a 33% solution in ethanol) and then triethylamine (0.159 ml, 1.1 mmol) was added to sulphanilyl fluoride (200 mg, 1.1 mmol), and the mixture heated at 80° C. for 6 hours then at ambient temperature for 18 hours. The volatiles were removed by evaporation and the residue azeotroped with toluene to give the title compound (160 mg, 76%). NMR: 2.30 (s, 3H), 5.85 (s, 2H), 6.60 (d, 2H), 7.39 (d, 2H); m/z: 187 [MH]+.

Aufarbeitung

  1. customThe volatiles were removed by evaporation
  2. customthe residue azeotroped with toluene

Quellen und Nachweise

ORD-Eintrag
ord-6672536baecc4bce82f56c30b796dbe9
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855719B1

Notizen zur Reaktion

Wird geladen…