Sulfanilamide → HCID 178512579, Verbindung

HRID 23926

Reaktionsgleichung

Reaktionsgleichung von HRID 23926
[S:1]([NH2:11])(=[O:10])([C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[CH:5][CH:4]=1)=[O:2].C([NH:20][C:21]#[N:22])(=O)C1C=CC=CC=1>C(O)C.Cl>[S:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:21]([NH2:22])=[NH:20])=[CH:7][CH:8]=1)(=[O:10])(=[O:2])[NH2:11]

Komponenten

5

Edukt 2

HCID 5333SulfanilamideHCID 84805Benzamide, N-cyano-

Produkt 1

HCID 178512579HCID 178512579, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of sulphanilamide (20 g, 0.166 mol), benzoyl cyanamide (34 g, 0.33 mmol) in ethanol (60 ml) and concentrated hydrochloric acid (11 ml) was heated on a steam bath until the solvent had evaporated. Water was added and the mixture heated at reflux for 5 minutes. Sodium hydroxide (14.4 g) was added and the mixture heated at reflux. The mixture was allowed to cool and was adjusted to pH2 with hydrochloric acid and the precipitated solid removed by filtration. The filtrate was neutralised and the solvent removed by evaporation. The residue was recrystallized from water to give crude title product. m/z: 215 [MH]+.

Aufarbeitung

  1. temperaturewas heated on a steam bath until the solvent
  2. customhad evaporated
  3. additionWater was added
  4. temperaturethe mixture heated
  5. temperatureat reflux for 5 minutes
  6. additionSodium hydroxide (14.4 g) was added
  7. temperaturethe mixture heated
  8. temperatureat reflux
  9. temperatureto cool
  10. customthe precipitated solid removed by filtration
  11. customthe solvent removed by evaporation
  12. customThe residue was recrystallized from water

Quellen und Nachweise

ORD-Eintrag
ord-ee291c72eff94acdb24dbeb334b42ea7
Quelldatensatz
uspto-grants-2005_02
Patentnummer
US06855719B1

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