Hydrochloric Acid → Methyl (R)-2-(4-hydroxyphenoxy)propionate
Reaktionsgleichung
C([O:4][C:5]1[CH:17]=[CH:16][C:8]([O:9][C@H:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])=[CH:7][CH:6]=1)(=O)C.Cl>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][C@H:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])=[CH:16][CH:17]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A mixture of 45 g (189 mmol) of methyl (R)-2-(4-acetoxyphenoxy)propionate (enantiomeric excess 94-95%), 135 ml of methanol and 2.5 ml of methanol saturated with gaseous hydrogen chloride was refluxed for 5 h and subsequently concentrated. The crude product was purified by distillation at 140° C. under 0.1 mbar. Yield: 96% (94-95% enantiomeric excess).
Aufarbeitung
- temperaturewas refluxed for 5 h
- concentrationsubsequently concentrated
- distillationThe crude product was purified by distillation at 140° C. under 0.1 mbar
Quellen und Nachweise
- ORD-Eintrag
- ord-221fdf92b5cc45bd9fbc54f9021c4ee5
- Quelldatensatz
- uspto-grants-1998_09
- Patentnummer
- US05801272
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