tert-Butanol → HCID 18979069, Verbindung

HRID 2393094Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2393094
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6](C(O)=O)=[N:7]2.[C:17]([OH:21])([CH3:20])([CH3:19])[CH3:18].C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:29])C=CC=CC=1.C([N:41]([CH2:44]C)CC)C>>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([NH:41][C:44]([O:21][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:29])=[N:7]2

Komponenten

5

Edukt 4

HCID 6386tert-ButanolHCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 99436352-Quinolinecarboxylic acid, 5-bromo-8-methoxy-

Produkt 1

HCID 18979069HCID 18979069, Verbindung

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

5-Bromo-8-methoxyquinoline-2-carboxylic acid (2 g), t-butanol (25 ml) and triethylamine (1.48 ml) were combined under a nitrogen atmosphere and heated to 80° C. Diphenylphosphorylazide (2.29 ml) was added to the solution and heating was continued for 60 h by which time a white preciptate was present. The reaction mixture was evaporated in vacuo onto silica and purified by flash chromatography to give the title compound (1.21 g) as an off white solid.

Aufarbeitung

  1. temperatureheating
  2. customThe reaction mixture was evaporated in vacuo onto silica
  3. custompurified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-8fd8d820442340eda5fdae2f56b55428
Quelldatensatz
uspto-grants-1998_09
Patentnummer
US05804588

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