Hydrochloric Acid → HCID 7440508, Verbindung

HRID 2393101Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2393101
C[O:2][C:3](=[O:27])[C@H:4]([NH:15][S:16]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1)(=[O:18])=[O:17])[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1.[OH-].[Na+].Cl>C(O)C>[CH3:26][O:25][C:22]1[CH:23]=[CH:24][C:19]([S:16]([NH:15][C@H:4]([CH2:5][C:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[NH:8][CH:7]=2)[C:3]([OH:27])=[O:2])(=[O:17])=[O:18])=[CH:20][CH:21]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 6977080HCID 6977080, Verbindung

Produkt 1

HCID 7440508HCID 7440508, VerbindungAusbeute 93 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To 1.3 mmol of 2(R)-[(4-methoxybenzenesulfonyl)amino]-3-(3-indolyl)-propanoic acid methyl ester suspended in 15 mL of ethanol is added 5 mL of aqueous 2.5M sodium hydroxide. The solid suspension dissolved, and is allowed to stir at ambient temperature overnight. The mixture is acidified with aqueous 10% HCl and extracted with ethyl acetate. The organic phase is washed with brine and dried over sodium sulfate. It is concentrated to afford 0.45 g (93%) of a white solid,

Aufarbeitung

  1. dissolutionThe solid suspension dissolved
  2. extractionextracted with ethyl acetate
  3. washThe organic phase is washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationIt is concentrated

Quellen und Nachweise

ORD-Eintrag
ord-16035cd2f2244980a445b7fe7e8c4424
Quelldatensatz
uspto-grants-1998_09
Patentnummer
US05804593

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