Acrylamide → Phenidone

HRID 2393342Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2393342
[C:1]1([NH:7][NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:9](N)(=[O:12])[CH:10]=[CH2:11].[OH-].[K+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[C:1]1([N:7]2[CH2:11][CH2:10][C:9](=[O:12])[NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 6579AcrylamideHCID 7516PhenylhydrazineHCID 14797Potassium Hydroxide

Produkt 1

HCID 7090Phenidone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 74236Tetrabutylammonium BromideKatalysator

Versuchsvorschrift

Phenylhydrazine (10.8 g, 0.1 mol), and acrylamide (7.8 g, 0.11 mol), pulverized potassium hydroxide (12.5 g, 0.22) and a catalytic amount of tetrabutylammonium bromide is refluxed for 30 minutes. The precipitate is filtered and washed with toluene. The crystalline sold is dissolved in water. Acidification with acetic acid, filtration and drying gives 1-phenyl-3-pyrazolidone.

Aufarbeitung

  1. filtrationThe precipitate is filtered
  2. washwashed with toluene
  3. dissolutionThe crystalline sold is dissolved in water
  4. filtrationAcidification with acetic acid, filtration
  5. customdrying

Quellen und Nachweise

ORD-Eintrag
ord-a82caac1fad34dcb8cdc22597bbf516d
Quelldatensatz
uspto-grants-1998_09
Patentnummer
US05807863

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