Sodium Hydroxide → 5,5-Dimethoxypentanoic acid

HRID 2393687Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2393687
[CH3:1][O:2][CH:3]([O:11][CH3:12])[CH2:4][CH2:5][CH2:6][C:7]([O:9]C)=[O:8].[OH-].[Na+]>CO>[CH3:12][O:11][CH:3]([O:2][CH3:1])[CH2:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 551444Methyl 5,5-dimethoxyvalerate

Produkt 1

HCID 118050725,5-Dimethoxypentanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

12 mmoles methyl 5,5-dimethoxypentanoate (Stevens, R. V. et al., J Am Chem Soc (1979) 7054) were dissolved in 20 ml 50% aqueous methanol. 16 mmoles NaOH were added and the mixture was stirred for 2 hr at room temperature. The solvent was then evaporated, the residue layered with 30 ml EtOAc, and the sodium salt neutralized with ice-cold 1N HCl. The aqueous phase was extracted with an additional 20 ml EtOAc, the organic extracts combined and dried over K2CO3. The product was filtered and the solvent evaporated to provide 5,5-dimethoxypentanoic acid.

Aufarbeitung

  1. customThe solvent was then evaporated
  2. extractionThe aqueous phase was extracted with an additional 20 ml EtOAc
  3. dry with materialdried over K2CO3
  4. filtrationThe product was filtered
  5. customthe solvent evaporated

Quellen und Nachweise

ORD-Eintrag
ord-f0f9e1b9ecc04f6c96d765e11669395d
Quelldatensatz
uspto-grants-1998_09
Patentnummer
US05807979

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