Methoxyacetic Acid → Methoxyacetic Acid
Reaktionsgleichung
[NH:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH2:10][CH2:11][CH2:12][N:13]([CH3:31])[CH2:14][CH2:15][C:16]1([OH:30])[CH2:25][CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[C:21]([F:26])[CH:22]=2)[CH:17]1[CH:27]([CH3:29])[CH3:28].[CH3:32][O:33][CH2:34][C:35]([OH:37])=[O:36]>>[CH3:32][O:33][CH2:34][C:35]([OH:37])=[O:36].[CH3:32][O:33][CH2:34][C:35]([O:30][C:16]1([CH2:15][CH2:14][N:13]([CH2:12][CH2:11][CH2:10][C:2]2[NH:3][C:4]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[N:1]=2)[CH3:31])[CH2:25][CH2:24][C:23]2[C:18](=[CH:19][CH:20]=[C:21]([F:26])[CH:22]=2)[CH:17]1[CH:27]([CH3:28])[CH3:29])=[O:36]Komponenten
4
Edukt 2
Produkt 2
Versuchsvorschrift
The method of claim 9 further including the step of contacting the thus-formed 2-[2-{[3-(1H-benzimidazol-2-yl)propyl]methylamino}ethyl]-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-ol with methoxyacetic acid or an activated derivative of methoxyacetic acid to form 2-[2-{[3-(1H-benzimidazol-2-yl)propyl]methylamino}ethyl]-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl methoxyacetate.
Quellen und Nachweise
- ORD-Eintrag
- ord-4d39fee87fa24001b69298582580c42e
- Quelldatensatz
- uspto-grants-1998_09
- Patentnummer
- US05808088
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