4-Chlorobenzenesulfonyl isocyanate → 3-[(4-Chlorophenyl)sulfonyl]-7,8-dimethyl-2,4(1H,3H)-quinazolinedione
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]=[C:12]=[O:13])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH2:14][C:15]1[C:23]([CH3:24])=[C:22]([CH3:25])[CH:21]=[CH:20][C:16]=1[C:17](O)=[O:18]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([S:8]([N:11]2[C:17](=[O:18])[C:16]3[C:15](=[C:23]([CH3:24])[C:22]([CH3:25])=[CH:21][CH:20]=3)[NH:14][C:12]2=[O:13])(=[O:9])=[O:10])=[CH:6][CH:7]=1Komponenten
3
Versuchsvorschrift
365 mg (1.68 mmol) of 4-chlorobenzenesulfonylisocyanate and 230 mg (1.40 mmol) of 2-amino-3,4-dimethylbenzoic acid were treated in the same way as in Example 1 to obtain 272 mg of the above-identified compound (yield 53.6%). Properties: colorless crystal, Melting point; 241°-245° C., PMR (δppm, DMSO-d6): 2.21 (3H,s), 2.32 (3H,s), 7.06 (1H,d), 7.63 (1H,d), 7.75 (2H,d), 8.18 (2H,d), 10.64 (1H,br).
Quellen und Nachweise
- ORD-Eintrag
- ord-38a2a7c8126c438da8e477cc51554bb1