Potassium Hydroxide → 5-bromo-6-methoxy-1H-indole-2-carboxylic acid

HRID 2395769Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2395769
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([O:15]C)=[O:14])=[CH:5]2.[OH-].[K+]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[O:11][CH3:12])[NH:7][C:6]([C:13]([OH:15])=[O:14])=[CH:5]2

Komponenten

3

Edukt 2

HCID 14797Potassium HydroxideHCID 16726758methyl 5-bromo-6-methoxy-1H-indole-2-carboxylate

Produkt 1

HCID 194188695-bromo-6-methoxy-1H-indole-2-carboxylic acid

Versuchsvorschrift

Following the general procedure of PREPARATION 63 and making non-critical variations but starting with methyl 5-bromo-6-methoxyindole carboxylate (PREPARATION 81, 3.31 g) and potassium hydroxide (0.98 g), the title compound is obtained, NMR (300 MHz, CD3OD) 7.79, 7.03, 7.01 and 3.89 δ.

Aufarbeitung

  1. customthe general procedure of PREPARATION 63

Quellen und Nachweise

ORD-Eintrag
ord-a5e183ffc1aa497a846807de9d038e6d
Quelldatensatz
uspto-grants-1996_02
Patentnummer
US05489593

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