Hydrochloric Acid → HCID 23359009, Verbindung

HRID 2396957Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2396957
[F:1][C:2]1[C:11]([CH3:12])=[C:10]([F:13])[C:9]([F:14])=[C:8]([N+:15]([O-:17])=[O:16])[C:3]=1[NH:4]C(=O)C.Cl.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[F:1][C:2]1[C:11]([CH3:12])=[C:10]([F:13])[C:9]([F:14])=[C:8]([N+:15]([O-:17])=[O:16])[C:3]=1[NH2:4]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 23359014HCID 23359014, Verbindung

Produkt 1

HCID 23359009HCID 23359009, VerbindungAusbeute 118,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To 2,4,5-trifluoro-3-methyl-6-nitro-N-acetylaniline (2.08 g) are added ethanol (30 ml) and 10% hydrochloric acid (30 ml) and the mixture is refluxed for 3 hours. After cooling, the reaction mixture is poured into ice-water, neutralized with potassium carbonate, extracted with dichloromethane and the extract is dried. The solvent is distilled off under reduced pressure to give 2,4,5-trifluoro-3-methyl-6-nitroaniline (2.05 g), as brown crystals.

Aufarbeitung

  1. temperaturethe mixture is refluxed for 3 hours
  2. temperatureAfter cooling
  3. extractionextracted with dichloromethane
  4. customthe extract is dried
  5. distillationThe solvent is distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f7bf96c01bc84d0f9d25370b7344087f
Quelldatensatz
uspto-grants-1996_02
Patentnummer
US05495020

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