HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
6-Methoxy-9H-purine → (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxirane
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 6-Methoxy-9H-purine | HCID 70632 | — |
| Edukt | (1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol | HCID 10631861 | — |
| Edukt | (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-7(7H)-purinyl]ethyl]oxirane | HCID 22859142 | — |
| Produkt | (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxirane | HCID 18657628 | 21,1% |
Reaktionsschritte
Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (523 mg) and 6-methoxypurine 1/2 hydrate (415 mg), (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-7(7H)purinyl]ethyl]oxirane (205 mg) and (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl]oxirane (183 mg) were obtained as a white powder respectively by the same way as in Reference Example 2.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05495024 |
| Quelldatensatz | uspto-grants-1996_02 |
| ORD ID | ord-cf7180fde80649579b3443b9df903eff |
| Quellennotiz | uspto-grants-1996_02 |