p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

HRID 2397624Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2397624
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH2:3][C:4]#[N:5].NCC[C@@H:14]([OH:20])[CH2:15][CH2:16][CH2:17][CH2:18]C.O.[C:22]1([CH3:32])[CH:27]=[CH:26][C:25]([S:28]([OH:31])(=[O:30])=[O:29])=[CH:24][CH:23]=1>>[C:22]1([CH3:32])[CH:23]=[CH:24][C:25]([S:28]([OH:31])(=[O:29])=[O:30])=[CH:26][CH:27]=1.[NH2:5][CH2:4][CH2:3][C@@H:2]([O:1][CH:14]1[CH2:15][CH2:16][CH2:17][CH2:18][O:20]1)[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]

Komponenten

5

Edukt 3

HCID 521998p-Toluenesulfonic acid monohydrateHCID 134138033-HydroxycaprylonitrileHCID 227975051-amino-3(S)-octanol

Produkt 2

HCID 6101p-Toluenesulfonic acidHCID 540303281-Amino-3(S)-(tetrahydro-2H-pyran-2-yloxy)octane

Versuchsvorschrift

This compound is prepared essentially by the same method as described in Example 1, Step A-2, except that the 3-hydroxycaprylonitrile is replaced by 1-amino-3(S)-octanol and slightly more than one equivalent of p-toluenesulfonic acid. hydrate is used. This method provides the p-toluenesulfonic acid salt of the title compound which is converted to the oily title compound by distribution between dilute sodium hydroxide and ether. The organic phase is washed with saturated aqueous brine, dried over sodium sulfate, and filtered. Evaporation of the filtrate in vacuo leaves the title compound as a residual oil.

Aufarbeitung

  1. customThis compound is prepared essentially by the same method

Quellen und Nachweise

ORD-Eintrag
ord-15fdaa5ece704e8285f39984a93db8c1
Quelldatensatz
uspto-grants-1977_05
Patentnummer
US04022794

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